Plasma Porphyrins in Lead Workers.
نویسنده
چکیده
Plasma porphyrin levels were determined in a group of 50 workers exposed to lead. The mean value obtained (0 7 ug./100 ml.) was found to be higher than that obtained from a control group (0-2 ,ug./100 ml.). Although urinary porphyrin levels in the lead workers were also higher than in the control group, no correlation was found between plasma porphyrin levels and urinary porphyrin levels. Chromatography of the plasma porphyrins from lead workers showed that some protoporphyrin was present in addition to the coproporphyrin found in plasma from the control group.
منابع مشابه
Lead poisoning in a group of demolition workers.
The incidence of lead poisoning in industry has fallen dramatically since the beginning of the twentieth century. This reduction has been partly attributable to increased awareness, improved ventilation and hygiene facilities, and technical changes which have allowed other substances to replace lead, but improved medical surveillance of workers exposed to lead in certain defined industries has ...
متن کاملInvestigations of factors influencing exposure and response to lead, mercury, and cadmium in man and in animals.
The susceptibility of the heme biosynthetic pathway to lead, as reflected by increased free erythrocyte porphyrin (FEP) concentration, is in humans as well as in rats in the order of young greater than or equal to female greater than male. The difference between adult male and female rats can be explained at least partially by the interaction of estradiol and progesterone with the FEP response ...
متن کاملA simplified method for rapid determination of porphyrins by thin-layer chromatography.
Free porphyrins, especially copro-, uro-, and protoporphyrin, were successfully separated by talc thin-layer chromatography (TLC), and were determined from the relationship of the weight and the area of porphyrins in the spot on the thin-layer plate. The results obtained from both the solvent extraction and the simple, rapid TLC method reported in this paper showed good correlation for copropor...
متن کاملSynthesis and Application of New Gadolinium-Porphyrins as Potential MR Imaging Contrast Agents for Cancer Detection in Nude Mice
Two new potential magnetic resonance imaging contrast agents, Gd-hematoporphyrin (Gd-H) and Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd TCP), were synthesized and applied to nude mice with human melanoma (MM 138) xenografts. These agents showed a high relaxivity because of their greater potential to coordinate water molecules. The reduction of T1 relaxation times of 16 and 21% was observed i...
متن کاملپایش بیولوژیکی و محیطی سرب و اثرات تماس با آن در صنعت خودرو سازی
Background and Aims: Soldering is one of the most common activities in metal industries. Lead is used in soldering process and has considerable toxic effects. The aim of this study, therefore, was biological and environmental monitoring and investigating the effects of exposure to lead in soldering unit workers at an automobile industry. Methods: In order to evaluate biological and enviro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British journal of industrial medicine
دوره 21 شماره
صفحات -
تاریخ انتشار 1964